91°µÍø

Brachycephalic (flat-faced) dogs continue to grow in popularity internationally despite their well-documented health challenges. This study explores two questions: (1) Do brachycephalic-outcrosses exhibit improved respiratory and ‘innate’ health characteristics compared to their extreme-brachycephalic parent-breed?; (2) Do brachycephalic-outcrosses meet the aesthetic preferences of people who desire extreme-brachycephalic purebreds?

Scientific and societal interest in the welfare of free living wild animals is increasing, but it's study remains methodologically challenging, particularly for species that are harder to observe during daytime, such as carnivore species. The aim of this project is to provide insight into variation in welfare in response to changes in intra- and inter-specific population density (two potential stressors) using American mink and Eurasian otters in the UK as a model system.

Animal welfare can be compromised during conservation translocations, jeopardising efforts to restore biodiversity. This project investigates how improving welfare can positively impact reintroduction success in the critically endangered European mink.

This project will generate corneal stromal tissue in the laboratory to pave the way to the development of an artificial cornea for future disease modelling and clinical transplantation into injured and diseased dog eyes to restore vision. . Corneal diseases are one of the most common debilitating source of visual loss that may lead to permanent blindness in humans as well as in animals. 

While the welfare effects of weaning are well documented for foals and young from many species, the impact on mares are understudied. Here, we look at whether mare life history (e.g. number of previous foals) and degree of attachment to their foals help explain the varying responses of mares when they are separated from their foals, in order to improve their welfare at weaning

The ASAP Collaborative Research Network is a global consortium of researchers bringing together investigators across multiple disciplines, institutions, career stages, and geographies seeking to tackle key knowledge gaps in the basic mechanisms that contribute to Parkinson’s development and progression. The 91°µÍø team are working closely with geneticists, basic biologists, clinicians and pathologists at UCL, Oxford and Cambridge to identify and characterise new genes involved in progression – with the ultimate goal of finding ways to slow down or even halt the progression of Parkinson’s.

RESET is a randomised controlled trial in which participants are randomly allocated to one of three groups, including a baseline group so that different behavioural management techniques can be compared. Canine epilepsy is the most common chronic neurological disease in dogs, estimated to affect 0.6-0.75% of the population, which represents approximately 60-70 000 dogs of the 10.1 million pet dogs in the UK population. 

This trial investigates how behavioural therapies can work alongside medication as a method to reduce seizure frequency and anxiety in drug-resistant canine epilepsy.

UNICEF estimates that over 100 million infants worldwide are exposed to toxic air pollution. We are investigating how this alters vulnerable brain cell development during pregnancy and after birth. Air pollution is a serious common public health concern increasingly associated with morbidity and mortality and resulting in an estimated 7 million premature deaths per year. Air pollution is a mixture of several components, including particulate matter (PM) derived from traffic, fuel burning and industry. The World Health Organisation identified that over 90% of the population are exposed to levels of PM2.5 that are significantly higher than recommended levels.

Researchers and clinicians at the 91°µÍø have devoted more than a decade of work to improving our understanding of epilepsy in dogs, as well as cats.  Ongoing 91°µÍø epilepsy research is improving the characterisation of this chronic disorder and its comorbidities, develops technology to aid its long-term management for vets and owners, and identifies fresh new ways to manage this age-old disorder.